The Blues put in their most impressive performance of the season to maintain their 100% start to the season, taking it to seven wins from seven games. Prolific loan striker, Ben Mills, scored a hat-trick and Iain Howard added a fourth as Guiseley were outplayed from the off.
Chester had an early opportunity as Steve Drench spilled a Dave Hankin cross and after just alluding Ben Mills it fell to Antoni Sarcevic but his shot was scuffed and Guiseley were able to clear away.
The home side didn't have to wait long to get another effort and it was prolific striker Ben Mills on hand again. George Horan's flick on from an Antoni Sarcevic cross found Marc Williams who played the ball to Mills, after getting the ball under control he struck the ball high, past Steve Drench and into the roof of the net.
Guiseley were nearly back level as James Walshaw rounded John Danby but his shot from an angle rebounded back of the outside of the Chester post.
The home side had another chance after some excellent link-up play between Antoni Sarcevic and Marc Williams, the latter forcing Steve Drench into a good save.
The Blues didn't have to wait long before increasing their lead as Ben Mills shot from outside the area went straight through Steve Drench and in for his second of the same.
Shortly before half time Chester had an appeal for a penalty as Ben Mills appeared to be pushed down in the box but appeals were waved away by the referee before Antoni Sarcevic's effort went just over the bar.
Chester increased their lead early in the second half as Wes Baynes' free kick hit long towards George Horan, his header back across goal was headed home by Ben Mills. completing his hat-trick.
The home team continued to pressure and George Horan had a header cleared off the line before Antoni Sarcevic saw his effort from the edge of the area well saved by Drench.
Guiseley tried to get back in the game as captain, Simon Ainge, saw his header go just wide from a Jamie Clarke cross.
The home side completed the rout with five minutes to go as Dave Hankin broke well, running at the heart of the Guiseley defence, he found Iain Howard who unleashed a fierce drive into the bottom corner, across Steve Drench.
Chester: Danby, Baynes, McGinn, Horan (c), Linwood, Mackin, Hankin, Sarcevic (Howard), M Williams, Mills (Jarman), Brown (A Williams)
Subs not used: Collins, Powell
Goal Scorers: Ben Mills 5, 25, 60, Howard 84.
Guiseley: Drench, Holdsworth, McWilliams, Meynell (Clarke), Ellis, Ainge (c), Brogan (Brooksby), Boshell (Dale), Wilson, Walshaw, Rothery
Subs not used: Bower, Brooksby, Giles
Man of the match: Chester - Ben Mills, Guiseley - Steve Drench
Referee: Mr M Ackerman
Assistant Referee: Mr M Corlett, Mr S Mycock
Match Report by Chris Graham